Skip to content Resources to improve your home plus a chance to win $10K Register Login Content starts here Join Renew Health Caution! These Drugs Can Cause Memory Loss Check your medicine cabinet if you’re experiencing forgetfulness, brain fog or confusion By Rachel Nania and Aaron Kassraie, Updated April 30, 2025 AARP By Zachary Cox, PharmD 539 En español Updated April 30, 2025 iStockphoto Drugs That May Cause Memory Loss Antianxiety drugs • Antiseizure drugs • Tricyclic antidepressants (older class) • Narcotic painkillers • Sleeping aids • Incontinence drugs • Antihistamines (first generation) For a long time, doctors dismissed forgetfulness, brain fog and mental confusion as normal parts of aging. But scientists now know that memory loss as you get older is by no means inevitable. In fact, routine memory, skills and knowledge may even improve with age, acco...